{"product_id":"small-stoppering-r-d-freeze-dryer","title":"Small Stoppering R\u0026D Freeze Dryer","description":"\u003ch2\u003eSmall Stoppering R\u0026amp;D Freeze Dryer – QualiRFD™ 6S\u003c\/h2\u003e\n\u003cp\u003eQualiRFD™ 6S Freeze Dryer is a compact pilot R\u0026amp;D unit designed for vial-based lyophilization with integrated stoppering. It enables the development of stable drying cycles and preserves product quality during storage.\u003c\/p\u003e\n\u003cp\u003eThis system allows testing and process exploration that mirrors production practices, while keeping batch sizes manageable for development. Freezing and drying occur within the same chamber, minimizing handling and ensuring consistent, repeatable results.\u003c\/p\u003e\n\u003cp\u003eFeaturing a dual-chamber design, the QualiRFD™ 6S includes a drying chamber and a cold trap (condenser) that efficiently captures sublimated vapor under controlled vacuum conditions.\u003c\/p\u003e\n\u003cp\u003eThe stoppering function seals vials immediately after drying, reducing moisture uptake and lowering the risk of contamination during storage and transport. The control interface supports recipe-driven operation, allowing multi-step temperature programs to be stored and executed for precise cycle development.\u003c\/p\u003e\n\u003cp\u003eApplications\u003c\/p\u003e\n\u003cp\u003eLyophilized vials for pharmaceutical R\u0026amp;D: Formulation teams use the Freeze Dryer to screen excipient systems, define safe product temperatures, and fine-tune primary and secondary drying steps. Stoppering under controlled conditions supports better post-drying stability when your product must remain sealed until use.\u003c\/p\u003e\n\u003cp\u003eBiotech reagents and sensitive biological samples: Many proteins, enzymes, and biological reagents benefit from low residual moisture and controlled drying curves. Programmable segments and stable temperature control help you run repeatable trials when activity retention and reconstitution behavior matter.\u003c\/p\u003e\n\u003cp\u003eDiagnostics and research kits packaged in vials: Vial-based Freeze Dryer workflows are common for IVD reagents and research kits that need long storage life. The stoppering step helps protect dried material from humidity pickup after the cycle ends.\u003c\/p\u003e\n\u003cp\u003eSpecialty materials and chemical R\u0026amp;D: Freeze drying supports porous structures, powders, and other lab-scale materials where controlled ice structure and drying rate affect final morphology. The system is positioned for development work where cycle changes must be tested quickly and compared with consistent data logging.\u003c\/p\u003e\n\u003cp\u003eHere’s an SEO-optimized rephrasing of your “Applications” section, keeping it clear, professional, and without the restricted words:\u003c\/p\u003e\n\u003ch2\u003eApplications of the Small Stoppering R\u0026amp;D Freeze Dryer – QualiRFD™ 6S\u003c\/h2\u003e\n\u003cp\u003eLyophilized vials for pharmaceutical R\u0026amp;D: Ideal for formulation testing, the freeze dryer allows teams to screen excipient systems, determine safe product temperatures, and optimize primary and secondary drying steps. Controlled stoppering enhances post-drying stability for products that must remain sealed until use.\u003c\/p\u003e\n\u003cp\u003eBiotech reagents and sensitive biological samples: Proteins, enzymes, and other biological reagents benefit from low residual moisture and precise drying profiles. Programmable temperature segments and stable control ensure repeatable trials while preserving activity and reconstitution performance.\u003c\/p\u003e\n\u003cp\u003eDiagnostics and research kits in vials: Suitable for IVD reagents and research kits, the vial-based workflow ensures long-term stability. Stoppering immediately after drying protects sensitive materials from humidity and maintains quality during storage.\u003c\/p\u003e\n\u003cp\u003eSpecialty materials and chemical R\u0026amp;D: Supports lab-scale development of powders, porous structures, and other materials where ice structure and drying rates impact final morphology. The system enables rapid cycle testing with consistent data logging for reliable comparisons.\u003c\/p\u003e\n\u003ch3\u003eStandards Compliance – QualiRFD™ 6S Freeze Dryer\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eISO 13408-3: Provides guidance for controlling and validating lyophilization as an aseptic process, particularly relevant for vial stoppering workflows.\u003c\/li\u003e\n\u003cli\u003eASTM E2500: Outlines a science- and risk-based methodology for specifying, designing, and verifying pharmaceutical and biopharmaceutical equipment and systems.\u003c\/li\u003e\n\u003cli\u003eISO 14644-1 \/ ISO 14644-2: Covers cleanroom classification and monitoring, commonly referenced when installing the freeze dryer in controlled environments.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSmall Stoppering R\u0026amp;D Freeze Dryer – QualiRFD™ 6S Key Features\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIn-situ vacuum operation: Freezing and drying occur in a single chamber, minimizing handling and ensuring consistent results.\u003c\/li\u003e\n\u003cli\u003eIntegrated stoppering mechanism: Seals vial caps immediately after drying to reduce moisture absorption and lower contamination risk.\u003c\/li\u003e\n\u003cli\u003eDual-chamber design: Includes a drying chamber and cold trap for efficient vapor capture during sublimation.\u003c\/li\u003e\n\u003cli\u003eIndependent shelf temperature probes: Monitor samples at each shelf level to support development trials and validation runs.\u003c\/li\u003e\n\u003cli\u003ePrecise temperature control: Shelf accuracy ±1 °C with PLC control and PID regulation for stable, repeatable cycles.\u003c\/li\u003e\n\u003cli\u003eOptimized cooling and heating: Cold trap cooling performance combined with controlled shelf temperature ramps for reliable cycle development.\u003c\/li\u003e\n\u003cli\u003eAdvanced touchscreen interface: Data-rich screens, stored programs, and up to 36 configurable segments per cycle for stepwise operation.\u003c\/li\u003e\n\u003cli\u003eFlexible cycle adjustments: Edit parameters or skip segments during automatic operation to accelerate development work.\u003c\/li\u003e\n\u003cli\u003eNitrogen backfill option: Allows use of inert gas during drying or at the end of the cycle for sensitive products.\u003c\/li\u003e\n\u003cli\u003eSafety and maintenance features: Alerts, vacuum\/refrigeration protections, maintenance reminders, audible alarms, and emergency stop functionality.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eTheory and Method – QualiRFD™ 6S Freeze Dryer\u003c\/h2\u003e\n\u003cp\u003eFreeze drying (lyophilization) removes solvent through controlled freezing, sublimation, and desorption under reduced pressure. The process begins by freezing the product on temperature-controlled shelves, which defines ice structure and affects mass transfer during drying.\u003c\/p\u003e\n\u003cp\u003eDuring primary drying, chamber pressure is lowered, allowing ice to sublimate directly into vapor, which is captured by the cold trap at low temperature. Secondary drying follows, reducing bound moisture through controlled shelf temperature holds under vacuum until the target residual moisture is achieved.\u003c\/p\u003e\n\u003cp\u003eThe integrated stoppering function adds a closure step at the end of the cycle. Vials can be pre-filled, and the mechanism seals caps after drying to limit rehydration and protect the dried product. This workflow ensures vial-based R\u0026amp;D closely mirrors production practices, supporting reliable and repeatable cycle development.\u003c\/p\u003e\n\u003ch2\u003eSmall Stoppering R\u0026amp;D Freeze Dryer – QualiRFD™ 6S Technical Specification\u003c\/h2\u003e\n\u003ctable class=\"table\" border=\"1\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecification\u003c\/th\u003e\n\u003cth\u003eUnit\u003c\/th\u003e\n\u003cth\u003eQualiRFD™ S\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eFreeze drying area\u003c\/td\u003e\n\u003ctd\u003em²\u003c\/td\u003e\n\u003ctd\u003e0.2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCold trap temperature (no-load)\u003c\/td\u003e\n\u003ctd\u003e°C\u003c\/td\u003e\n\u003ctd\u003e\u0026lt; -75\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVacuum level (no-load)\u003c\/td\u003e\n\u003ctd\u003ePa\u003c\/td\u003e\n\u003ctd\u003e≤ 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eShelf temperature range (no-load)\u003c\/td\u003e\n\u003ctd\u003e°C\u003c\/td\u003e\n\u003ctd\u003e-55 to +70\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMaximum ice capacity\u003c\/td\u003e\n\u003ctd\u003ekg\/24h\u003c\/td\u003e\n\u003ctd\u003e≥ 6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNumber of shelf layers\u003c\/td\u003e\n\u003ctd\u003epcs\u003c\/td\u003e\n\u003ctd\u003e2 + 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMaterial tray size\u003c\/td\u003e\n\u003ctd\u003emm\u003c\/td\u003e\n\u003ctd\u003e400 × 270\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eShelf spacing\u003c\/td\u003e\n\u003ctd\u003emm\u003c\/td\u003e\n\u003ctd\u003e100\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOverall power\u003c\/td\u003e\n\u003ctd\u003ekW\u003c\/td\u003e\n\u003ctd\u003e4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight\u003c\/td\u003e\n\u003ctd\u003ekg\u003c\/td\u003e\n\u003ctd\u003e300\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDimensions (W × L × H)\u003c\/td\u003e\n\u003ctd\u003emm\u003c\/td\u003e\n\u003ctd\u003e1033 × 781 × 1704\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLoadable materials\u003c\/td\u003e\n\u003ctd\u003eL\/kg\u003c\/td\u003e\n\u003ctd\u003e2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLoadable vials (Φ12 mm)\u003c\/td\u003e\n\u003ctd\u003epcs\u003c\/td\u003e\n\u003ctd\u003e1554\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLoadable vials (Φ16 mm)\u003c\/td\u003e\n\u003ctd\u003epcs\u003c\/td\u003e\n\u003ctd\u003e868\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLoadable vials (Φ22 mm)\u003c\/td\u003e\n\u003ctd\u003epcs\u003c\/td\u003e\n\u003ctd\u003e440\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDefrost mode\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003ctd\u003eElectric defrost\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSafety devices\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003ctd\u003eAudible alarm, emergency stop, overpressure protection\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVoltage\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003ctd\u003eSingle-phase 3-wire, 220 V (110V is also available)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Qualitest USA LC","offers":[{"title":"Default Title","offer_id":51846955991351,"sku":null,"price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0786\/1859\/1543\/files\/small-stoppering-rd-freeze-dryer1424906136.webp?v=1775040931","url":"https:\/\/qualitest.us\/pt\/products\/small-stoppering-r-d-freeze-dryer","provider":"Qualitest USA LC","version":"1.0","type":"link"}