{"product_id":"extra-large-r-d-freeze-dryer","title":"Extra Large R\u0026D Freeze Dryer","description":"\u003ch2\u003eExtra Large R\u0026amp;D Freeze Dryer – QualiRFD™ 15\u003c\/h2\u003e\n\u003cp\u003eAchieving reliable scale-up from lab formulations to pilot batches depends on precise freeze-drying performance. The QualiRFD™ 15 Freeze Dryer is designed for R\u0026amp;D teams requiring consistent cycle development, complete process visibility, and stable control of critical parameters as experiments move toward production scale. Its in-situ workflow allows pre-freezing and drying within a single chamber, minimizing handling steps and supporting cleaner, more uniform results.\u003c\/p\u003e\n\u003cp\u003eThis in-situ vacuum Freeze Dryer is ideal for process exploration, formulation testing, and small-batch pilot studies in both regulated and industrial laboratories. The unit integrates a drying chamber with a low-temperature condenser (cold trap) to efficiently capture sublimated vapor while keeping vacuum conditions steady. A transparent chamber door allows live monitoring during freezing, primary drying, and secondary drying, enabling observation of product behavior without interrupting the cycle.\u003c\/p\u003e\n\u003cp\u003eThe recipe-driven control system enables stepwise temperature ramps and holds, letting teams create, save, and repeat cycles during optimization. Key parameters such as shelf temperature, product temperature, cold trap temperature, and vacuum are recorded automatically, simplifying trial comparisons and supporting precise process adjustments.\u003c\/p\u003e\n\u003ch2\u003eApplications of the Extra Large R\u0026amp;D Freeze Dryer – QualiRFD™ 15\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePharmaceutical R\u0026amp;D and Lyophilized Dosage Development:\u003c\/strong\u003e\u003cbr\u003eIdeal for developing and optimizing lyophilization cycles for injectables and other pharmaceutical formulations. Researchers can control freezing rates, define primary drying limits, and verify secondary drying targets to enhance product stability and shelf life.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBiotechnology and Life Science Sample Preservation:\u003c\/strong\u003e\u003cbr\u003eSupports lyophilization of proteins, antibodies, enzymes, and other biomolecules for long-term storage, safe transport, and downstream testing. Precise shelf temperature and vacuum control reduce collapse risk while preserving bioactivity upon reconstitution.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIn Vitro Diagnostic and Research Reagents:\u003c\/strong\u003e\u003cbr\u003eEnables development and pilot-scale batches for IVD reagents and similar products, ensuring low residual moisture and stable storage. Consistent cycle performance simplifies method transfer from development to controlled pilot production.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaterials and Chemical Research:\u003c\/strong\u003e\u003cbr\u003eSuitable for preparing porous structures, powders, polymers, coatings, and films. Controlled drying curves minimize deformation and maintain repeatable morphology, supporting reliable comparative studies in materials research.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnvironmental Sample Preparation:\u003c\/strong\u003e\u003cbr\u003eFacilitates processing of environmental samples such as soil or water extracts for analytical studies. Recorded cycle data ensures consistent preparation across experiments and over time.\u003c\/p\u003e\n\u003ch3\u003eStandards and Compliance\u003c\/h3\u003e\n\u003cp\u003eThe QualiRFD™ 15 Extra Large R\u0026amp;D Freeze Dryer is designed to align with recognized industry standards, ensuring safe and validated operation in pharmaceutical, biotech, and life science laboratories:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eISO 13408-3: Provides guidance for control and validation of lyophilization processes in aseptic production of healthcare products.\u003c\/li\u003e\n\u003cli\u003eASTM E2500: Supports a risk-based approach for specification, design, and verification of pharmaceutical and biopharmaceutical manufacturing systems and equipment.\u003c\/li\u003e\n\u003cli\u003eISO 14644-1 \/ ISO 14644-2: Covers cleanroom air cleanliness classification and monitoring, essential when freeze-dryer operation is conducted in controlled or GMP environments.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eExtra Large R\u0026amp;D Freeze Dryer – QualiRFD™ 15 Key Features\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIn-Situ Workflow: Freezing and drying occur within the same chamber, reducing handling steps and delivering more consistent results.\u003c\/li\u003e\n\u003cli\u003eDual-Chamber Design: Combines a drying chamber and cold trap to capture vapor efficiently during sublimation.\u003c\/li\u003e\n\u003cli\u003eTransparent Chamber Door: Enables real-time observation of the freeze-drying process without interrupting the run.\u003c\/li\u003e\n\u003cli\u003ePID Shelf Temperature Control: Maintains precise shelf temperatures to ensure uniform drying across all shelf positions.\u003c\/li\u003e\n\u003cli\u003eFreeze-Drying Curve Management: Supports stepwise ramps and holds throughout freezing, sublimation, and desorption, aiding process optimization.\u003c\/li\u003e\n\u003cli\u003eInert Gas Backfill: Controlled valve allows post-drying backfill to protect sensitive samples.\u003c\/li\u003e\n\u003cli\u003eRecipe Management: Stores multi-segment temperature programs for repeatable experimentation and small-batch pilot runs.\u003c\/li\u003e\n\u003cli\u003eComprehensive Data Trending: Records and exports cold trap, product, and vacuum curves for documentation and cycle development.\u003c\/li\u003e\n\u003cli\u003eFlexible Operation Modes: Offers manual or automatic modes for hands-on experimentation or consistent batch execution.\u003c\/li\u003e\n\u003cli\u003eAlarm History and Access Control: Supports troubleshooting, maintenance workflows, and secure operation in regulated environments.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eTheory and Method – Extra Large R\u0026amp;D Freeze Dryer – QualiRFD™ 15\u003c\/h2\u003e\n\u003cp\u003eFreeze drying removes solvents under vacuum through controlled stages that preserve product integrity:\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1. Freezing and Ice Formation\u003c\/strong\u003e\u003cbr\u003eThe product is cooled on temperature-controlled shelves until the solvent crystallizes. The freezing rate determines ice crystal size, which directly affects mass transfer during drying.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e2. Primary Drying (Sublimation)\u003c\/strong\u003e\u003cbr\u003eVacuum is applied, and shelf temperature is carefully raised to sublimate ice directly into vapor. The vapor is captured by the cold trap. Controlled temperature ramps and holds prevent product collapse or melt-back, ensuring uniform drying.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3. Secondary Drying (Desorption)\u003c\/strong\u003e\u003cbr\u003eOnce most ice has sublimated, shelf temperature is increased to remove residual bound water or solvent. Segmented cycles enable repeatable studies, targeting precise residual moisture levels and predictable reconstitution performance.\u003c\/p\u003e\n\u003ch2\u003eExtra Large R\u0026amp;D Freeze Dryer – QualiRFD™ 15 Technical Specification\u003c\/h2\u003e\n\u003ctable class=\"table\" border=\"1\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eItem\u003c\/th\u003e\n\u003cth\u003eUnit\u003c\/th\u003e\n\u003cth\u003eQualiRFD™ XL\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eFreeze-drying area\u003c\/td\u003e\n\u003ctd\u003em²\u003c\/td\u003e\n\u003ctd\u003e1.03\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRecommended loading capacity\u003c\/td\u003e\n\u003ctd\u003ekg\u003c\/td\u003e\n\u003ctd\u003e10\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCold trap temperature (no-load)\u003c\/td\u003e\n\u003ctd\u003e°C\u003c\/td\u003e\n\u003ctd\u003e\u0026lt; -75\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUltimate vacuum level (no-load)\u003c\/td\u003e\n\u003ctd\u003ePa\u003c\/td\u003e\n\u003ctd\u003e≤ 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eShelf temperature range (no-load)\u003c\/td\u003e\n\u003ctd\u003e°C\u003c\/td\u003e\n\u003ctd\u003e-55 to +70\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMaximum ice capacity\u003c\/td\u003e\n\u003ctd\u003ekg\/24h\u003c\/td\u003e\n\u003ctd\u003e≥ 15\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNumber of shelf layers\u003c\/td\u003e\n\u003ctd\u003epcs\u003c\/td\u003e\n\u003ctd\u003e6 + 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTray size\u003c\/td\u003e\n\u003ctd\u003emm\u003c\/td\u003e\n\u003ctd\u003e480 × 360\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eShelf spacing\u003c\/td\u003e\n\u003ctd\u003emm\u003c\/td\u003e\n\u003ctd\u003e70\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOverall power\u003c\/td\u003e\n\u003ctd\u003ekW\u003c\/td\u003e\n\u003ctd\u003e6.5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight\u003c\/td\u003e\n\u003ctd\u003ekg\u003c\/td\u003e\n\u003ctd\u003e700\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDimensions\u003c\/td\u003e\n\u003ctd\u003emm\u003c\/td\u003e\n\u003ctd\u003e876 × 1190 × 1727\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Qualitest USA LC","offers":[{"title":"Default Title","offer_id":51846934298935,"sku":null,"price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0786\/1859\/1543\/files\/extra-large-rd-freeze-dryer2085945382.webp?v=1775040596","url":"https:\/\/qualitest.us\/fr\/products\/extra-large-r-d-freeze-dryer","provider":"Qualitest USA LC","version":"1.0","type":"link"}