{"product_id":"water-cooled-freeze-dryer","title":"Water Cooled Freeze Dryer","description":"\u003ch2\u003eWater Cooled Freeze Dryer – QualiWCFD Series\u003c\/h2\u003e\n\u003cp\u003eThe QualiWCFD Series Water Cooled Freeze Dryer supports longer pilot runs with consistent heat removal and precise cycle control. Ideal for laboratory research, small-scale trials, and pilot production, it enables seamless preparation before full-scale manufacturing.\u003c\/p\u003e\n\u003cp\u003eDesigned for cycle development and validation, the system offers a freeze-drying area from 0.5 m² to 5 m² and feeding capacity ranging between 5 kg and 50 kg. Water serves as the cooling medium, paired with a reliable Bitzer refrigeration unit for stable operation.\u003c\/p\u003e\n\u003cp\u003eThis pilot-scale Freeze Dryer bridges the gap between lab-scale experiments and industrial production, allowing repeated trials to confirm process feasibility, optimize recipes, and minimize surprises during scale-up.\u003c\/p\u003e\n\u003cp\u003eFeatures include controlled shelf temperature, deep vacuum performance, and a cold trap optimized for efficient vapor capture during sublimation. Optional CIP and SIP capabilities ensure elevated hygiene standards in regulated environments.\u003c\/p\u003e\n\u003ch2\u003eApplications – Water Cooled Freeze Dryer\u003c\/h2\u003e\n\u003cp\u003eSmall-batch trials and pilot production: Water-cooled freeze dryers are ideal for producing limited batches while the process window is being fine-tuned. This stage provides consistent performance for product teams before moving to full-scale production equipment.\u003c\/p\u003e\n\u003cp\u003eRepeated experiments for cycle optimization: Multiple freeze-drying runs allow confirmation of process feasibility and fine adjustment of freezing ramps, chamber pressure settings, and shelf temperature profiles. This method reduces development risk and enables faster iteration on formulations and container selections.\u003c\/p\u003e\n\u003cp\u003eValidation prior to formal production: Pilot-scale testing supports feasibility assessments and documentation, offering structured verification for projects requiring qualification-style deliverables.\u003c\/p\u003e\n\u003cp\u003eLaboratory research, pilot trials, and scale-up studies: R\u0026amp;D teams utilize pilot systems to study product behavior, confirm critical temperatures, and evaluate batch-to-batch consistency. Water-cooled configurations are preferred when steady condenser performance and frequent runs are needed.\u003c\/p\u003e\n\u003cp\u003eSmall-scale production with smoother scale-up: Pilot units can perform small-scale production while maintaining process similarity with larger systems. This ensures a more seamless transition from development to production planning when the same control strategy is applied.\u003c\/p\u003e\n\u003ch3\u003eStandards – Water Cooled Freeze Dryer\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eISO 13408-3 (Lyophilization as an aseptic process): Provides guidance for controlling and validating lyophilization equipment and processes to ensure reliable aseptic operation.\u003c\/li\u003e\n\u003cli\u003eISO 13408-4 (Clean-in-place technologies): Defines requirements and best practices for applying CIP to product-contact surfaces, ensuring hygienic and efficient cleaning.\u003c\/li\u003e\n\u003cli\u003eISO 13408-5 (Sterilization in place): Specifies guidance for SIP procedures on product-contact surfaces, supporting high hygiene standards in regulated environments.\u003c\/li\u003e\n\u003cli\u003eASTM E2500 (Verification of pharmaceutical and biopharmaceutical systems): Offers a risk-based framework for the specification, design, and verification of equipment and systems, aligning with industry compliance expectations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWater Cooled Freeze Dryer – QualiWCFD Series Key Features\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003ePilot-scale design for small-scale trials: Ideal for laboratory research, pilot production, and early-stage process development before full-scale manufacturing.\u003c\/li\u003e\n\u003cli\u003eFlexible capacity range: Covers 0.5–5 m² freeze-drying shelf area and 5–50 kg feeding capacity, supporting diverse pilot programs.\u003c\/li\u003e\n\u003cli\u003eDeep vacuum performance: Achieves ≤ 1 Pa (no-load) for precise sublimation control during drying.\u003c\/li\u003e\n\u003cli\u003eEfficient vapor capture: Cold trap reaches temperatures of ≤ −75°C to ensure effective ice condensation during primary drying.\u003c\/li\u003e\n\u003cli\u003eWide shelf temperature range: From −55°C to +70°C, enabling freezing, controlled drying, and secondary drying phases.\u003c\/li\u003e\n\u003cli\u003eControlled ramp rates: Heating and cooling rates of 1°C\/min support consistent and repeatable freeze-drying cycles.\u003c\/li\u003e\n\u003cli\u003eReliable refrigeration: Equipped with a Bitzer refrigeration unit for stable water-cooled operation.\u003c\/li\u003e\n\u003cli\u003eHygienic workflow options: Optional CIP and SIP functions maintain high hygiene standards in regulated environments.\u003c\/li\u003e\n\u003cli\u003eStructured validation support: Documentation includes DQ, IQ, and OQ to facilitate structured deployment and verification.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eTheory and Method – Water Cooled Freeze Dryer\u003c\/h2\u003e\n\u003cp\u003eFreeze drying removes water from products through three main stages under vacuum: freezing, primary drying, and secondary drying. During freezing, the ice structure forms, influencing mass transfer and the final cake quality. Primary drying drives sublimation, with vapor captured on the cold trap to maintain stable chamber pressure. In secondary drying, bound moisture is removed through controlled shelf temperature holds, achieving the desired residual moisture content.\u003c\/p\u003e\n\u003ch2\u003eWater Cooled Freeze Dryer – QualiWCFD Series Technical Specification\u003c\/h2\u003e\n\u003ctable class=\"table\" border=\"1\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecification\u003c\/th\u003e\n\u003cth\u003eUnit\u003c\/th\u003e\n\u003cth\u003eQualiWCFD\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eFreeze-drying area\u003c\/td\u003e\n\u003ctd\u003em²\u003c\/td\u003e\n\u003ctd\u003e0.5 to 5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFeeding capacity\u003c\/td\u003e\n\u003ctd\u003ekg\u003c\/td\u003e\n\u003ctd\u003e5 to 50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCold trap temperature\u003c\/td\u003e\n\u003ctd\u003e°C\u003c\/td\u003e\n\u003ctd\u003e≤ -75\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVacuum degree\u003c\/td\u003e\n\u003ctd\u003ePa\u003c\/td\u003e\n\u003ctd\u003e≤ 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eShelf temperature range\u003c\/td\u003e\n\u003ctd\u003e°C\u003c\/td\u003e\n\u003ctd\u003e-55 to +70\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHeating and cooling rate\u003c\/td\u003e\n\u003ctd\u003e°C\/min\u003c\/td\u003e\n\u003ctd\u003e1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCooling method\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003ctd\u003eWater cooling\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRefrigeration unit\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003ctd\u003eBitzer refrigeration unit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOptional functions\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003ctd\u003eCIP, SIP\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eValidation documents (listed)\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003ctd\u003eDQ, IQ, OQ\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Qualitest USA LC","offers":[{"title":"Default Title","offer_id":51847001014583,"sku":null,"price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0786\/1859\/1543\/files\/water-cooled-freeze-dryer1042034375.webp?v=1775042358","url":"https:\/\/qualitest.us\/ar\/products\/water-cooled-freeze-dryer","provider":"Qualitest USA LC","version":"1.0","type":"link"}